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UNILAG Researchers Collaboration With Global Consortium Unravels Novel Parkinson’s Genetics Risk Factor In Africans and African Admixed Populations

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Photo : ▪︎Prof. Njideka Okubadejo, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos.


Akoka, Lagos – Researchers from the University of Lagos are key collaborators in the Global Parkinson’s Genetics Program (GP2) that uncovered a genetic variant that increases the risk of Parkinson’s Disease (PD) in Africans and African admixed populations.

The research finding was the result of teamwork by an international team including the Nigeria Parkinson Disease Research (NPDR) network, the International Parkinson’s Disease Genomics Consortium (IPDGC)-Africa, University College London, the National Institutes of Health (NIH) in
the US, and 23andMe.

The study was funded by the Michael J Fix foundation for Parkinson’s research and GP2.

The NPDR network and UNILAG team are led by a Professor of Neurology in the Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Professor Njideka Okubadejo who acknowledges the crucial role that the supportive research environment at the
university and the commitment of the national and international partners played in the success of the team.

She said “This GBA1 result is a step toward that future, where the research field is
prioritizing, learning from, and treating all people with Parkinson’s disease.”

Other members of the UNILAG team collaborating with the Global consortium (GP2) include: Dr. Oluwadamilola ‘Lara’ Ojo (Associate Professor and Site Lead Investigator, Faculty of
Clinical Sciences (FCS);
Dr. Osigwe Agabi (FCS);
Prof. Francis Ojini (FCS)
and Dr. Ismail Ishola (Faculty of Basic Medical Sciences (FBMS). 
Others are Dr. Francisca Nwaokorie (Associate Professor, FBMS); Mr. Roosevelt Anyanwu (Central Research Laboratory CMUL), and Dr. Arinola Sanyaolu (FBMS).

The variant on the GBA1 gene was identified by the GP2 researchers as part of efforts to galvanize international/collaborative research into the genetics of Parkinson’s Disease (PD) as well as revolutionize treatment for the African and African admixed population.

While more research is needed to define the exact mechanism of the new variant, initial findings also suggest that like prior mutations in GBA1, this variant results in lowered activity of the glucocerebrosidase (GCase) enzyme.

The Global Parkinson’s Genetics Program (GP2) is a resource programme of the Aligning Science Across Parkinson’s (ASAP) initiative, it is funded by the Sergey Brin Family Foundation and implemented by The Michael J. Fox Foundation for Parkinson’s Research (MJFF).

The Aligning Science Across Parkinson’s (ASAP) launched GP2 in 2019 to follow up on previous funding efforts from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) with a view to expanding global genetics study in populations traditionally underrepresented in research.

Till date, the GP2 is partnering with over 140 cohorts from around the world, assembling,
generating and sharing data to uncover novel insights and similarities in Parkinson’s Disease (PD).

The Vice-Chancellor, University of Lagos, Professor Folasade Ogunsola, on behalf of the University Senate, Management, Staff and Students, congratulates the UNILAG team on the GP2 project for their impact in the latest discovery.

Professor Ogunsola says the UNILAG team’s input and impact on the GP2 further accentuates the university’s fast migration into a Future-Ready institution with imprints in various fields including
Science.

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Gov Mbah Invest in world-class Enugu International Hospital

The hospital, equipped with state-of-the-art medical equipment and advanced digital and electronic systems, is expected to attract top medical professionals from Nigeria and around the world.

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Enugu State Governor, Peter Mbah, says the Enugu International Hospital is designed to provide world-class healthcare services to people across all socioeconomic classes.

The Enugu International Hospital is located at Rangers Avenue, Independence Layout, Enugu.

Mbah stated this during a pre-launch tour of the facility ahead of its official commissioning.

The hospital, equipped with state-of-the-art medical equipment and advanced digital and electronic systems, is expected to attract top medical professionals from Nigeria and around the world.

The governor expressed satisfaction with the quality of the equipment installed at the facility, saying the investment would help position Enugu as a medical tourism hub in Nigeria.

He said the hospital would also help reduce the number of Nigerians travelling abroad for specialist medical treatment while creating an environment that would encourage Enugu-trained medical professionals to return home.

According to Mbah, several Enugu-qualified medical practitioners based abroad have already reached out to express interest in working at the international hospital and contributing to the development of the state’s health sector.

The governor further said the facility would create job opportunities for medical graduates, healthcare professionals and other workers, with the potential to boost economic activity in the state.

During the tour, Mbah inspected several specialist units, including the Precision Oncology and Nuclear Medicine Unit, specialised surgery theatres, intensive care units, advanced diagnostics and imaging, and renal care and dialysis facilities.

He also toured the cancer, heart and vascular, nuclear medicine and molecular imaging, neuroscience, and renal centres.

Accompanied by the Director of the facility, Professor Sam Agwu, and other specialists, the governor received briefings on the various services and specialist care the hospital is expected to provide.

The Enugu International Hospital operates as a comprehensive quaternary care facility with more than 300 beds and was established to provide world-class specialist healthcare.

The facility is expected to strengthen access to advanced medical care, support medical professionals, create employment and contribute to Enugu State’s emergence as a destination for medical tourism.

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Bayer to establish reproductive health commodities plant in Nigeria

The plant is expected to manufacture family planning commodities locally, reducing Nigeria’s dependence on imported products, creating jobs and contributing to economic growth.

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•The Minister of Health and Social Welfare, Prof. Muhammad Pate

Global pharmaceutical company, Bayer, is to establish a reproductive health commodities manufacturing plant in Nigeria, with the facility currently under construction in Anambra State.

The plant is expected to manufacture family planning commodities locally, reducing Nigeria’s dependence on imported products, creating jobs and contributing to economic growth.

The Minister of Health and Social Welfare, Prof. Muhammad Pate, disclosed this in Abuja at the inauguration of the High-Level Inter-Ministerial Platform (IMP) on Family Planning, Health, Human Capital and Sustainable National Development.

Pate described the investment as evidence that President Bola Tinubu’s Executive Order on the pharmaceutical sector was beginning to attract significant investments in local pharmaceutical manufacturing, diagnostics and health technology.

Also speaking, the Managing Director of FP2030 West and Central Africa Office, Dr Alain Damiba, described the initiative as a major step towards strengthening cross-sector collaboration to improve health outcomes and accelerate Nigeria’s socio-economic development.

Damiba commended the Federal Government for adopting a whole-of-government approach, noting that the new platform demonstrated that health and family planning were national development priorities and not issues that should be left to the health sector alone.

“Health, including family planning, is a smart investment in human capital and Nigeria’s future,” Damiba said.

Source: The Guardian Nigeria

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Medical Oxygen Killing More Than 600,000 Nigerians Annually

The project started its first phase by carrying out intervention work in three industrial areas of the state: quarry industrial site in Onueke, rice mill in Abakaliki, and timber market

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•Professor Jesse Uneke

The Vice Chancellor of David Umahi Federal University of Health Sciences (DUFUS), Ebonyi State, Professor Jesse Uneke, has estimated that more than 600,000 Nigerians died yearly due to issues relating to the administration of medical oxygen.

Uneke, who is the Nigerian and State Lead/Principal Investigator for the EQUI-RESP Africa Research Project, disclosed this in Abakaliki, during the First Stakeholders’ Engagement Event/Co-Creation Workshop on Medical Oxygen Economy organised by the university in conjunction with the University of Edinburgh, UK, supported by the National Institute for Health and Research (NIHR), UK.

He explained that the administration of medical oxygen issues was happening because there was no platform where stakeholders in the medical oxygen space could come together to discuss the research-policy interface and see how to contextualise some of the strategies against the problems for the country.

“That is why, in this phase of this project, we have decided to start with this kind of stakeholders’ engagement. I am excited that we have every key stakeholder in the medical oxygen space represented here,” Uneke said.

He opined that the project started its first phase by carrying out intervention work in three industrial areas of the state: quarry industrial site in Onueke, rice mill in Abakaliki, and timber market.

This project has to do with respiratory health, and the idea is to come up with strategies that will lead to interventions that will improve health outcomes as far as respiratory health is concerned.

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