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UNILAG Researchers Collaboration With Global Consortium Unravels Novel Parkinson’s Genetics Risk Factor In Africans and African Admixed Populations

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Photo : ▪︎Prof. Njideka Okubadejo, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos.


Akoka, Lagos – Researchers from the University of Lagos are key collaborators in the Global Parkinson’s Genetics Program (GP2) that uncovered a genetic variant that increases the risk of Parkinson’s Disease (PD) in Africans and African admixed populations.

The research finding was the result of teamwork by an international team including the Nigeria Parkinson Disease Research (NPDR) network, the International Parkinson’s Disease Genomics Consortium (IPDGC)-Africa, University College London, the National Institutes of Health (NIH) in
the US, and 23andMe.

The study was funded by the Michael J Fix foundation for Parkinson’s research and GP2.

The NPDR network and UNILAG team are led by a Professor of Neurology in the Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Professor Njideka Okubadejo who acknowledges the crucial role that the supportive research environment at the
university and the commitment of the national and international partners played in the success of the team.

She said “This GBA1 result is a step toward that future, where the research field is
prioritizing, learning from, and treating all people with Parkinson’s disease.”

Other members of the UNILAG team collaborating with the Global consortium (GP2) include: Dr. Oluwadamilola ‘Lara’ Ojo (Associate Professor and Site Lead Investigator, Faculty of
Clinical Sciences (FCS);
Dr. Osigwe Agabi (FCS);
Prof. Francis Ojini (FCS)
and Dr. Ismail Ishola (Faculty of Basic Medical Sciences (FBMS). 
Others are Dr. Francisca Nwaokorie (Associate Professor, FBMS); Mr. Roosevelt Anyanwu (Central Research Laboratory CMUL), and Dr. Arinola Sanyaolu (FBMS).

The variant on the GBA1 gene was identified by the GP2 researchers as part of efforts to galvanize international/collaborative research into the genetics of Parkinson’s Disease (PD) as well as revolutionize treatment for the African and African admixed population.

While more research is needed to define the exact mechanism of the new variant, initial findings also suggest that like prior mutations in GBA1, this variant results in lowered activity of the glucocerebrosidase (GCase) enzyme.

The Global Parkinson’s Genetics Program (GP2) is a resource programme of the Aligning Science Across Parkinson’s (ASAP) initiative, it is funded by the Sergey Brin Family Foundation and implemented by The Michael J. Fox Foundation for Parkinson’s Research (MJFF).

The Aligning Science Across Parkinson’s (ASAP) launched GP2 in 2019 to follow up on previous funding efforts from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) with a view to expanding global genetics study in populations traditionally underrepresented in research.

Till date, the GP2 is partnering with over 140 cohorts from around the world, assembling,
generating and sharing data to uncover novel insights and similarities in Parkinson’s Disease (PD).

The Vice-Chancellor, University of Lagos, Professor Folasade Ogunsola, on behalf of the University Senate, Management, Staff and Students, congratulates the UNILAG team on the GP2 project for their impact in the latest discovery.

Professor Ogunsola says the UNILAG team’s input and impact on the GP2 further accentuates the university’s fast migration into a Future-Ready institution with imprints in various fields including
Science.

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Lagos Shuts Down YABATECH Sewage Plant Over Unauthorized Waste Discharge

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The Lagos State Government has sealed the sewage and wastewater treatment facility at Yaba College of Technology (YABATECH) following allegations that the institution was discharging raw, untreated sewage into the environment in violation of state environmental laws.

The enforcement action was carried out by the Lagos State Wastewater Management Office (LSWMO), operating under the Ministry of the Environment and Water Resources, after the college reportedly ignored multiple warning letters and failed to address long-standing environmental compliance issues.

Announcing the development, Commissioner for the Environment and Water Resources, Tokunbo Wahab, stated that the college’s actions constituted a serious breach of the Lagos State Environmental Management and Protection Law of 2017. The law explicitly prohibits the discharge of untreated wastewater or sewage into public drains, canals, or any part of the natural environment.

“The Lagos State Wastewater Management Office has sealed off the non-functional sewage and wastewater treatment facility of Yaba College of Technology due to its illegal discharge of raw sewage into the environment,” Wahab said in a statement.

He described the situation as a major public health risk, noting that untreated human waste contributes to the contamination of water sources, the spread of waterborne diseases, and general environmental degradation. Wahab emphasized that institutions, whether public or private, are not exempt from compliance with environmental laws and standards.

“Illegal discharge of wastewater not only endangers the health of residents but also undermines our efforts to maintain a sustainable, safe, and flood-resilient Lagos. The state government has zero tolerance for environmental infractions and will continue to enforce compliance,” the commissioner said.

#ZeroToleranceLagos Campaign

The sealing of YABATECH’s facility forms part of the state’s ongoing #ZeroToleranceLagos campaign—an initiative aimed at holding individuals, businesses, and institutions accountable for environmental violations. According to the Ministry, the campaign is designed to protect public health, improve environmental quality, and reduce pollution across Lagos.

Officials from the Wastewater Management Office said they had repeatedly engaged YABATECH’s management before resorting to enforcement. Technical guidance and timelines for achieving compliance were provided, but the institution allegedly failed to take corrective action.

Broader Enforcement Actions Across Lagos

In a related development, the Lagos State Environmental Protection Agency (LASEPA) has continued its crackdown on environmental violators across the state. On Thursday, the agency sealed 11 establishments in the Ikorodu area for various infractions, including persistent noise pollution, improper waste disposal, and failure to obtain necessary environmental permits.

The affected businesses include bars, hotels, lounges, and industrial facilities. Among those sealed are Zero Square Bar & Lounge, Limpex Resources, Starex Poly, Skipper Nigeria Ltd, NDO Hotel & Suites, Beechwood Guest House, Embassy Lounge, and A-Star Pencil.

The enforcement operation targeted several key areas in Ikorodu, such as Agodo Gas Line, Odogunyan Industrial Layout, Ita Oluwo Junction, Haruna, Ipakodo Road, and Ebute.

LASEPA stated that the crackdown is part of a broader effort to promote environmental responsibility and ensure that all sectors adhere to the state’s environmental protection framework.

Commitment to Sustainable Development

The Lagos State Government has reiterated its commitment to creating a healthier and more livable environment for its residents. Officials say that environmental compliance is central to the state’s climate resilience agenda and a critical step toward achieving its goals for a cleaner, greener Lagos.

Commissioner Wahab urged all public institutions, private companies, and individuals to align with the state’s environmental policies, warning that non-compliance would attract strict penalties, including fines, facility closures, and potential legal action.

“Lagos is committed to enforcing all existing environmental laws. Institutions must lead by example, and no one is above the law when it comes to protecting our environment,” Wahab added.

The situation at YABATECH serves as a stark reminder of the consequences of environmental negligence and the growing resolve of the Lagos State Government to ensure strict enforcement of environmental standards across the state.

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JUST IN: Doctors in FCT Commence Indefinite Strike Over Outstanding Issues

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The Association of Resident Doctors in the Federal Capital Territory Administration on Monday began an indefinite strike on Monday.

This was disclosed in a communique issued by the ARD-FCT on Monday, signed by its President, Dr. George Ebong, and General-Secretary, Dr. Agbor Affiong.

The association had embarked on a seven-day warning strike last Monday to press home its demands, following months of unresolved negotiations with the FCTA.

Details later.

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Overworked RSUTH Resident Doctor Slump, Dies on Duty

What happened is that he was on call in the Emergency Room. Afterward, he went to the call room to rest, and it was there that he died. Unfortunately, he was the only one attending to the patients.

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Dr Oluwafemi Rotifa, a young resident doctor at the Rivers State University Teaching Hospital (RSUTH) collapsed and died after a gruelling 72-hour call duty.

Ohibaba.com reliably gathered that the deceased doctor, fondly called Femoski by colleagues, was a former President of the Port Harcourt University Medical Students’ Association, PUMSA, and was registered with the United Kingdom’s General Medical Council, awaiting placement abroad.

The President of the Nigerian Association of Resident Doctors, NARD, Dr. Tope Osundara, who confirmed Rotifa’s death, said that the deceased doctor had been on continuous call duty for three days in the Emergency Room before he retreated to the call room to rest.

It was there that he slumped and later died, despite efforts to resuscitate him in the Intensive Care Unit.

“What happened is that he was on call in the Emergency Room. Afterward, he went to the call room to rest, and it was there that he died. Unfortunately, he was the only one attending to the patients.

“The overuse of manpower strained his health and led to this painful death. It was a death on duty,” Osundara lamented.

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