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UNILAG Researchers Collaboration With Global Consortium Unravels Novel Parkinson’s Genetics Risk Factor In Africans and African Admixed Populations

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Photo : ▪︎Prof. Njideka Okubadejo, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos.


Akoka, Lagos – Researchers from the University of Lagos are key collaborators in the Global Parkinson’s Genetics Program (GP2) that uncovered a genetic variant that increases the risk of Parkinson’s Disease (PD) in Africans and African admixed populations.

The research finding was the result of teamwork by an international team including the Nigeria Parkinson Disease Research (NPDR) network, the International Parkinson’s Disease Genomics Consortium (IPDGC)-Africa, University College London, the National Institutes of Health (NIH) in
the US, and 23andMe.

The study was funded by the Michael J Fix foundation for Parkinson’s research and GP2.

The NPDR network and UNILAG team are led by a Professor of Neurology in the Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Professor Njideka Okubadejo who acknowledges the crucial role that the supportive research environment at the
university and the commitment of the national and international partners played in the success of the team.

She said “This GBA1 result is a step toward that future, where the research field is
prioritizing, learning from, and treating all people with Parkinson’s disease.”

Other members of the UNILAG team collaborating with the Global consortium (GP2) include: Dr. Oluwadamilola ‘Lara’ Ojo (Associate Professor and Site Lead Investigator, Faculty of
Clinical Sciences (FCS);
Dr. Osigwe Agabi (FCS);
Prof. Francis Ojini (FCS)
and Dr. Ismail Ishola (Faculty of Basic Medical Sciences (FBMS). 
Others are Dr. Francisca Nwaokorie (Associate Professor, FBMS); Mr. Roosevelt Anyanwu (Central Research Laboratory CMUL), and Dr. Arinola Sanyaolu (FBMS).

The variant on the GBA1 gene was identified by the GP2 researchers as part of efforts to galvanize international/collaborative research into the genetics of Parkinson’s Disease (PD) as well as revolutionize treatment for the African and African admixed population.

While more research is needed to define the exact mechanism of the new variant, initial findings also suggest that like prior mutations in GBA1, this variant results in lowered activity of the glucocerebrosidase (GCase) enzyme.

The Global Parkinson’s Genetics Program (GP2) is a resource programme of the Aligning Science Across Parkinson’s (ASAP) initiative, it is funded by the Sergey Brin Family Foundation and implemented by The Michael J. Fox Foundation for Parkinson’s Research (MJFF).

The Aligning Science Across Parkinson’s (ASAP) launched GP2 in 2019 to follow up on previous funding efforts from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) with a view to expanding global genetics study in populations traditionally underrepresented in research.

Till date, the GP2 is partnering with over 140 cohorts from around the world, assembling,
generating and sharing data to uncover novel insights and similarities in Parkinson’s Disease (PD).

The Vice-Chancellor, University of Lagos, Professor Folasade Ogunsola, on behalf of the University Senate, Management, Staff and Students, congratulates the UNILAG team on the GP2 project for their impact in the latest discovery.

Professor Ogunsola says the UNILAG team’s input and impact on the GP2 further accentuates the university’s fast migration into a Future-Ready institution with imprints in various fields including
Science.

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ESUT inducts 70 graduates into nursing profession

The induction ceremony was conducted by the Registrar of the Nursing and Midwifery Council of Nigeria (NMCN), Alhaji Alhassan Ndagi, formally ushering the graduates into the noble healthcare profession.

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The Enugu State University of Science and Technology (ESUT), yesterday, inducted 70 pioneer graduates of its Department of Nursing Sciences into the nursing profession.

The induction ceremony was conducted by the Registrar of the Nursing and Midwifery Council of Nigeria (NMCN), Alhaji Alhassan Ndagi, formally ushering the graduates into the noble healthcare profession.

This was even as the elated inductees, who began their academic journey in 2018 without accreditation for the programme, heaped praises on the Enugu State Governor, Dr Peter Mbah, for the decisive action and strategic intervention, acknowledging that without the governor’s timely support and provision of the facilities necessary for accreditation, their dreams might have ended in frustration.

The Chairman of the occasion and Special Adviser to the Governor on Health, Dr Yomi Jaye, described the event as a celebration of vision, resilience, and political will.

He recounted how the students had been plunged into despair following years of delay due to the lack of accreditation until Mbah assumed office and swiftly ensured the programme met the standards required by the National Universities Commission (NUC) and the NMCN.

He said: “At the beginning of this administration, we were saddled with the task of strengthening our nursing and medical education.

We carried out a baseline assessment of all the institutions and discovered there was no accreditation for 19 years. We approached the NUC and the Nursing Council.

The governor backed us with all the necessary resources, and we worked alongside the university day and night. They didn’t just accredit them, they also indexed the backlog.”

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Six million donkeys slaughtered yearly for Chinese medicine – Report

It is driven by an increase in China’s production of ejiao – a product marketed as a health supplement that uses collagen from donkey skins – which is a $6.8-billion industry, according to China-based research firm Qianzhan.

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(AFP): Almost six million donkeys are slaughtered annually for Chinese medicine, with severe knock-on effects for African villagers who rely on the animals, a UK-based charity said on Thursday.

It is driven by an increase in China’s production of ejiao – a product marketed as a health supplement that uses collagen from donkey skins – which is a $6.8-billion industry, according to China-based research firm Qianzhan.

China, whose donkey population has plummeted from 11 million in 1992 to 1.5 million in 2023, has turned to Africa to meet its demand.

With donkey populations falling, the African Union issued a 15-year moratorium on donkey slaughter last year.

UK-based charity The Donkey Sanctuary said, “the ejiao industry drives a massive global trade in donkey skins, much of it illegal”.

It said around 5.9 million donkeys were killed worldwide last year.

The ejiao trade is expected to require at least 6.8 million donkey skins by 2027. The rising value of donkeys means they have increasingly become targets for criminals.

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Lagos State Enforcement Team Busts Illegal Abattoir in Agege, Arrests Operators

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The Lagos State enforcement squad of the MOE&WR led by KAI operatives on Wednesday burst an illegal abbatoir which was being operated at a private residence at Succo road directly opposite the RRS Barracks and LASTMA Yard in Oko Oba, Agege, arresting some of those found slaughtering animals for public consumption in the location.

The operation followed a tip-off from a whistle blower.

“The enforcement team said, the contaminated meat from cows and goats have been confiscated to prevent it from entering the food chain”.

“This action of the operators of the abbatoir is in defiance of the closure of the Oko Oba Abbatoir and poses great health dangers and environmental risks to the law abiding residents of the area”.

“We need to make it clear that such disregard for public health and sanitation will not be tolerated in Lagos State” .

“Every Government’s primary responsibility is the protection of lives and properties and we will not shirk that responsbbility.”

“We will continue to ensure that only safe and approved public facilities are allowed to operate within our communities.”the statement reads.

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