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UNILAG Researchers Collaboration With Global Consortium Unravels Novel Parkinson’s Genetics Risk Factor In Africans and African Admixed Populations

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Photo : ▪︎Prof. Njideka Okubadejo, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos.


Akoka, Lagos – Researchers from the University of Lagos are key collaborators in the Global Parkinson’s Genetics Program (GP2) that uncovered a genetic variant that increases the risk of Parkinson’s Disease (PD) in Africans and African admixed populations.

The research finding was the result of teamwork by an international team including the Nigeria Parkinson Disease Research (NPDR) network, the International Parkinson’s Disease Genomics Consortium (IPDGC)-Africa, University College London, the National Institutes of Health (NIH) in
the US, and 23andMe.

The study was funded by the Michael J Fix foundation for Parkinson’s research and GP2.

The NPDR network and UNILAG team are led by a Professor of Neurology in the Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Professor Njideka Okubadejo who acknowledges the crucial role that the supportive research environment at the
university and the commitment of the national and international partners played in the success of the team.

She said “This GBA1 result is a step toward that future, where the research field is
prioritizing, learning from, and treating all people with Parkinson’s disease.”

Other members of the UNILAG team collaborating with the Global consortium (GP2) include: Dr. Oluwadamilola ‘Lara’ Ojo (Associate Professor and Site Lead Investigator, Faculty of
Clinical Sciences (FCS);
Dr. Osigwe Agabi (FCS);
Prof. Francis Ojini (FCS)
and Dr. Ismail Ishola (Faculty of Basic Medical Sciences (FBMS). 
Others are Dr. Francisca Nwaokorie (Associate Professor, FBMS); Mr. Roosevelt Anyanwu (Central Research Laboratory CMUL), and Dr. Arinola Sanyaolu (FBMS).

The variant on the GBA1 gene was identified by the GP2 researchers as part of efforts to galvanize international/collaborative research into the genetics of Parkinson’s Disease (PD) as well as revolutionize treatment for the African and African admixed population.

While more research is needed to define the exact mechanism of the new variant, initial findings also suggest that like prior mutations in GBA1, this variant results in lowered activity of the glucocerebrosidase (GCase) enzyme.

The Global Parkinson’s Genetics Program (GP2) is a resource programme of the Aligning Science Across Parkinson’s (ASAP) initiative, it is funded by the Sergey Brin Family Foundation and implemented by The Michael J. Fox Foundation for Parkinson’s Research (MJFF).

The Aligning Science Across Parkinson’s (ASAP) launched GP2 in 2019 to follow up on previous funding efforts from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) with a view to expanding global genetics study in populations traditionally underrepresented in research.

Till date, the GP2 is partnering with over 140 cohorts from around the world, assembling,
generating and sharing data to uncover novel insights and similarities in Parkinson’s Disease (PD).

The Vice-Chancellor, University of Lagos, Professor Folasade Ogunsola, on behalf of the University Senate, Management, Staff and Students, congratulates the UNILAG team on the GP2 project for their impact in the latest discovery.

Professor Ogunsola says the UNILAG team’s input and impact on the GP2 further accentuates the university’s fast migration into a Future-Ready institution with imprints in various fields including
Science.

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Health

Federal Ministry of Health Orders Immediate Retirement of Directors After 8-Year Tenure

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The Federal Ministry of Health has directed the immediate retirement of all directors who have served at least eight years in the directorate cadre, effective from December 31, 2025.

The directive, outlined in a memo signed by Tetshoma Dafeta, Director overseeing the Office of the Permanent Secretary, enforces the eight-year tenure policy for directors as stipulated in Section 020909 of the Revised Public Service Rules 2021.

It applies to directors across the ministry, federal hospitals, agencies, and parastatals under its supervision.

The move aligns with a broader Federal Government circular from the Office of the Head of the Civil Service of the Federation, which reiterated the compulsory retirement rule for directors (Grade Level 17 or equivalent) after eight years in the position, as part of efforts to ensure compliance across all Ministries, Departments, and Agencies (MDAs).

The policy has sparked concerns from the Joint Health Sector Unions (JOHESU), which has criticized what it describes as selective implementation of retirement age reviews in the health sector.

JOHESU argues that such policies favor certain cadres over others, potentially undermining equity, teamwork, morale, and overall efficiency in healthcare delivery.

The ministry’s action follows recent government-wide enforcement of tenure limits for senior civil servants, including permanent secretaries. Affected directors are to be disengaged immediately, with institutions required to implement the directive without delay.

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More than 95,000 died of suicide so far in 2026 — WHO

Certain vulnerable populations face disproportionately higher risks, including refugees and migrants, indigenous peoples, LGBTI persons, prisoners, and others who experience discrimination, social exclusion or limited access to support services.

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World Health Organization (WHO) data reported that more than 95,000 people have died by suicide globally since the start of 2026.

According to Worldometer, the figure as of the time of this report, stands at 95, 406 so far in 2026.

The early-year toll highlights the continuing scale of suicide as a major global public health challenge.

WHO estimates show that about 727, 000 people die by suicide every year worldwide, with millions more attempting to take their own lives.

Health experts note that while annual suicide figures are usually released with a reporting delay, real-time counters help illustrate how frequently lives are lost to a largely preventable cause.

Suicide occurs across all regions and age groups, but WHO data indicate that it remains one of the leading causes of death among young people aged 15 to 29, ranking third globally in that age group in 2021.

The impact extends far beyond individuals, leaving long-lasting emotional, social and economic consequences for families, communities and entire nations.

Contrary to common assumptions, suicide is not limited to high-income countries.

WHO reports that nearly three-quarters (73%) of global suicides occur in low- and middle-income countries, where access to mental health care and social support services is often limited.

While suicide is closely linked to mental health conditions such as depression and alcohol use disorders, particularly in high-income countries,WHO notes that many suicides occur impulsively during moments of acute crisis.

These crises may stem from financial stress, relationship conflicts, chronic pain, illness, exposure to violence, displacement, or a profound sense of isolation.

Certain vulnerable populations face disproportionately higher risks, including refugees and migrants, indigenous peoples, LGBTI persons, prisoners, and others who experience discrimination, social exclusion or limited access to support services.

WHO stresses that suicide is preventable and requires a coordinated public health response rather than isolated interventions.

Evidence-based and often low-cost measures, such as restricting access to lethal means, promoting responsible media reporting, strengthening life skills among adolescents, and ensuring early identification and follow-up care for those at risk, have been shown to save

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WHO: United States membership withdrawal takes effect

Reacting to the development, WHO Director-General, Dr Tedros Adhanom Ghebreyesus, expressed regret over the decision and urged the United States to reconsider.

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The United States’ withdrawal from the World Health Organisation (WHO) officially took effect on Thursday, exactly one year after President Donald Trump ordered the country to pull out of the global health body.

Under the terms governing WHO membership, a withdrawal becomes effective after a mandatory one-year notice period, which expired on Thursday 22 January, following the executive order signed by Trump shortly after he took office in 2025.

Although the agreement requires the United States to settle all outstanding financial obligations before withdrawal, that condition has not been met. However, the WHO has no legal mechanism to enforce payment or prevent a member state from exiting the organisation.

Reacting to the development, WHO Director-General, Dr Tedros Adhanom Ghebreyesus, expressed regret over the decision and urged the United States to reconsider.

“The withdrawal is a loss for the United States and also a loss for the rest of the world,” Tedros said, adding that the organisation remains open to the country’s return.

President Trump had justified the decision by accusing the WHO of mishandling the COVID-19 pandemic, which originated in Wuhan, China, as well as other global health emergencies.

He also cited the organisation’s alleged failure to implement necessary reforms and its inability to operate independently of political influence from member states.

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