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UNILAG Researchers Collaboration With Global Consortium Unravels Novel Parkinson’s Genetics Risk Factor In Africans and African Admixed Populations

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Photo : ▪︎Prof. Njideka Okubadejo, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos.


Akoka, Lagos – Researchers from the University of Lagos are key collaborators in the Global Parkinson’s Genetics Program (GP2) that uncovered a genetic variant that increases the risk of Parkinson’s Disease (PD) in Africans and African admixed populations.

The research finding was the result of teamwork by an international team including the Nigeria Parkinson Disease Research (NPDR) network, the International Parkinson’s Disease Genomics Consortium (IPDGC)-Africa, University College London, the National Institutes of Health (NIH) in
the US, and 23andMe.

The study was funded by the Michael J Fix foundation for Parkinson’s research and GP2.

The NPDR network and UNILAG team are led by a Professor of Neurology in the Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Professor Njideka Okubadejo who acknowledges the crucial role that the supportive research environment at the
university and the commitment of the national and international partners played in the success of the team.

She said “This GBA1 result is a step toward that future, where the research field is
prioritizing, learning from, and treating all people with Parkinson’s disease.”

Other members of the UNILAG team collaborating with the Global consortium (GP2) include: Dr. Oluwadamilola ‘Lara’ Ojo (Associate Professor and Site Lead Investigator, Faculty of
Clinical Sciences (FCS);
Dr. Osigwe Agabi (FCS);
Prof. Francis Ojini (FCS)
and Dr. Ismail Ishola (Faculty of Basic Medical Sciences (FBMS). 
Others are Dr. Francisca Nwaokorie (Associate Professor, FBMS); Mr. Roosevelt Anyanwu (Central Research Laboratory CMUL), and Dr. Arinola Sanyaolu (FBMS).

The variant on the GBA1 gene was identified by the GP2 researchers as part of efforts to galvanize international/collaborative research into the genetics of Parkinson’s Disease (PD) as well as revolutionize treatment for the African and African admixed population.

While more research is needed to define the exact mechanism of the new variant, initial findings also suggest that like prior mutations in GBA1, this variant results in lowered activity of the glucocerebrosidase (GCase) enzyme.

The Global Parkinson’s Genetics Program (GP2) is a resource programme of the Aligning Science Across Parkinson’s (ASAP) initiative, it is funded by the Sergey Brin Family Foundation and implemented by The Michael J. Fox Foundation for Parkinson’s Research (MJFF).

The Aligning Science Across Parkinson’s (ASAP) launched GP2 in 2019 to follow up on previous funding efforts from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) with a view to expanding global genetics study in populations traditionally underrepresented in research.

Till date, the GP2 is partnering with over 140 cohorts from around the world, assembling,
generating and sharing data to uncover novel insights and similarities in Parkinson’s Disease (PD).

The Vice-Chancellor, University of Lagos, Professor Folasade Ogunsola, on behalf of the University Senate, Management, Staff and Students, congratulates the UNILAG team on the GP2 project for their impact in the latest discovery.

Professor Ogunsola says the UNILAG team’s input and impact on the GP2 further accentuates the university’s fast migration into a Future-Ready institution with imprints in various fields including
Science.

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Health

JUST IN: NAFDAC uncovers counterfeit drugs, expired condoms repackaged for sale at Lagos market

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The National Agency for Food and Drug Administration and Control has made alarming discoveries in its ongoing enforcement operation at the Idumota open drug market in Lagos.

The agency uncovered unregistered narcotics, counterfeit GlaxoSmithKline (GSK) medicines, and vaccines improperly stored, with some shockingly found in toilets.  

This was revealed in a statement shared on X (formerly Twitter) on Thursday. The statement reads, “In the ongoing enforcement operation at the Idumota open drug market, NAFDAC has uncovered more alarming products, including unregistered narcotics, counterfeit GSK medicines, and vaccines stored in toilets.  

“During an operation on Tuesday, officials also seized expired USAID-donated condoms, which had been repackaged and sold under the name “Kiss Condom.”

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The statement added, “More from the Idumota enforcement exercise, NAFDAC officials have seized, “Banned drugs such as Analgin, Vaccines meant for cold chain storage, Oxytocin for maternal health, improperly stored outside the cold chain and donated medical products.” 

NAFDAC has vowed to continue its crackdown on counterfeit and substandard medicines, emphasizing the grave health risks posed by these illicit products. The enforcement operation remains ongoing as officials work to dismantle illegal drug networks and ensure compliance with safety regulations.

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Kano gov signs bills to establish disease control, security agency

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Kano State Governor, Abba Kabir Yusuf, has signed into law the establishment of the state’s Disease Control Agency and the State Security Agency.

The governor signed the bills on Tuesday during the State Executive Council meeting held at the Kano Government House.

Additionally, the governor approved amendments to the law governing the Kano State Transport Agency.

The signing followed the Kano State House of Assembly’s approval of the bills.

During the same Executive Council meeting, Governor Abba honored students from science and technology secondary schools who excelled in various scientific and technological fields.

Among the awardees were Jafar Sani Muhd, who secured first place from Gwale Local Government Area, and Aminu Ado Abubakar, who came second, also from Gwale. Mustapha Nasir Mukhtar, from Bichi Local Government Area, secured third place.

Governor Abba Kabir Yusuf presented the students with various gifts, including computers.

The governor’s spokesperson, Sunusi Bature Dawakin Tofa, also presented to Governor Yusuf the 2024 Kano State Government’s work plan.

Furthermore, Governor Abba Kabir Yusuf received honorary awards from various organizations and institutions, including one from the Bishop Idahosa Foundation.

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36 per cent pregnant women suffer anaemia in Adamawa – UNICEF

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Thirty-six per cent of pregnant women in Adamawa State, according to the United Nations International Children’s Emergency Fund, UNICEF, suffer from anaemia, a condition that poses serious risks to both the mothers and their babies.

Nuzhat Rafique, the Chief of Field Office at UNICEF Bauchi, made the disclosure in Yola, explaining, “Adamawa State’s malnutrition crisis is further worsened by alarming child nutrition statistics: 48.6% of children are stunted, 7% are wasted, and over 80% experience child food poverty.”

She said to combat this crisis, UNICEF has provided 4,290 cartons of Small Quantity Lipid-Based Nutrient Supplements (SQ-LNS) to the Adamawa State government, assuring that the supplements will benefit approximately 85,000 children, helping to prevent malnutrition and improve child survival, growth, and development.

Addressing issues such as stunting, wasting, and anaemia, procured through the Child Nutrition Fund (CNF) mechanism, SQ-LNS contains 23 essential vitamins and minerals, as well as protein and energy.

According to her, Adamawa was among the first states in Nigeria to adopt the CNF, contributing N100 million in 2023, which was matched by UNICEF.

Felix Tangwami, Adamawa State’s Commissioner for Health and Human Resources, attributed the high malnutrition rates to insecurity, which has limited farmers’ access to their lands and reduced food availability.

He lauded Governor Ahmadu Umaru Fintiri for prioritizing the social services sector, particularly healthcare, and highlighted the state’s investment of N100 million in 2023 for food supplements, which has been increased to N300 million this year.

Dr. Bashir Sulaiman, the Executive Chairman of the Adamawa State Primary Healthcare Development Agency, expressed optimism that the N300 million matching fund would significantly improve child health in the state.

With UNICEF’s contribution, this will translate into N600 million worth of supplements, ensuring better nutrition and well-being for thousands of children.

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