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UNILAG Researchers Collaboration With Global Consortium Unravels Novel Parkinson’s Genetics Risk Factor In Africans and African Admixed Populations

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Photo : ▪︎Prof. Njideka Okubadejo, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos.


Akoka, Lagos – Researchers from the University of Lagos are key collaborators in the Global Parkinson’s Genetics Program (GP2) that uncovered a genetic variant that increases the risk of Parkinson’s Disease (PD) in Africans and African admixed populations.

The research finding was the result of teamwork by an international team including the Nigeria Parkinson Disease Research (NPDR) network, the International Parkinson’s Disease Genomics Consortium (IPDGC)-Africa, University College London, the National Institutes of Health (NIH) in
the US, and 23andMe.

The study was funded by the Michael J Fix foundation for Parkinson’s research and GP2.

The NPDR network and UNILAG team are led by a Professor of Neurology in the Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Professor Njideka Okubadejo who acknowledges the crucial role that the supportive research environment at the
university and the commitment of the national and international partners played in the success of the team.

She said “This GBA1 result is a step toward that future, where the research field is
prioritizing, learning from, and treating all people with Parkinson’s disease.”

Other members of the UNILAG team collaborating with the Global consortium (GP2) include: Dr. Oluwadamilola ‘Lara’ Ojo (Associate Professor and Site Lead Investigator, Faculty of
Clinical Sciences (FCS);
Dr. Osigwe Agabi (FCS);
Prof. Francis Ojini (FCS)
and Dr. Ismail Ishola (Faculty of Basic Medical Sciences (FBMS). 
Others are Dr. Francisca Nwaokorie (Associate Professor, FBMS); Mr. Roosevelt Anyanwu (Central Research Laboratory CMUL), and Dr. Arinola Sanyaolu (FBMS).

The variant on the GBA1 gene was identified by the GP2 researchers as part of efforts to galvanize international/collaborative research into the genetics of Parkinson’s Disease (PD) as well as revolutionize treatment for the African and African admixed population.

While more research is needed to define the exact mechanism of the new variant, initial findings also suggest that like prior mutations in GBA1, this variant results in lowered activity of the glucocerebrosidase (GCase) enzyme.

The Global Parkinson’s Genetics Program (GP2) is a resource programme of the Aligning Science Across Parkinson’s (ASAP) initiative, it is funded by the Sergey Brin Family Foundation and implemented by The Michael J. Fox Foundation for Parkinson’s Research (MJFF).

The Aligning Science Across Parkinson’s (ASAP) launched GP2 in 2019 to follow up on previous funding efforts from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) with a view to expanding global genetics study in populations traditionally underrepresented in research.

Till date, the GP2 is partnering with over 140 cohorts from around the world, assembling,
generating and sharing data to uncover novel insights and similarities in Parkinson’s Disease (PD).

The Vice-Chancellor, University of Lagos, Professor Folasade Ogunsola, on behalf of the University Senate, Management, Staff and Students, congratulates the UNILAG team on the GP2 project for their impact in the latest discovery.

Professor Ogunsola says the UNILAG team’s input and impact on the GP2 further accentuates the university’s fast migration into a Future-Ready institution with imprints in various fields including
Science.

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Health

Customs intercept expired pharmaceuticals at Apapa port

Adeniyi explained that on receipt of credible information, a 40ft container with registration number, MRSU6407089, was jointly examined by officers of the NCS and National Drug Law Enforcement Agency.

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The Nigeria Customs Service seized seven containers of expired drugs and prohibited medications, three containers of expired food items, particularly margarine, and three containers of absolutely prohibited used clothing at the Apapa port.

The Comptroller-General of Customs, Adewale Adeniyi, estimated that the duty paid values of the seizures made on Monday, arms included, was more than N10 billion.

Adeniyi explained that on receipt of credible information, a 40ft container with registration number, MRSU6407089, was jointly examined by officers of the NCS and National Drug Law Enforcement Agency.

The container was adjudged clean, but a secondary search by the two agencies revealed the concealment of 202 cans of Colorado loud, that is, Canadian drugs.

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Chikungunya: Could It Happen in Nigeria?

WHO’s Technical Lead for Arboviruses, Dr Diana Rojas-Alvarez said the warning was being sounded early to give countries a fighting chance.

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The World Health Organisation, WHO, on Monday warned of a global resurgence of chikungunya, a mosquito-borne viral disease, following major outbreaks in La Réunion, Mayotte, and Mauritius since March.

However, Nigeria is not yet on the list of countries currently battling chikungunya outbreaks, but public health experts warn that the nation’s environmental conditions make it highly susceptible.

The outbreaks, WHO said, have now spread to South and East Asia, mirroring patterns seen 20 years ago when a wave that began in the Indian Ocean swept across continents, infecting nearly half a million people.

“This further spread is highly concerning because it follows a trajectory we’ve seen before-one that can quickly escalate into a global public health emergency,” WHO stated in its advisory.

The agency also confirmed that the virus continues to spread in endemic regions, with the Americas already reporting over 200,000 cases this year alone.

WHO said that about 5.6 billion people worldwide now live in areas suitable for the spread of Aedes mosquitoes-the Aedes aegypti and Aedes albopictus which transmit chikungunya along with other diseases such as dengue and Zika.

Chikungunya has been detected or transmitted in 119 countries globally. In communities with little or no immunity, WHO warned that the disease can infect up to three-quarters of the population in a short period, severely straining healthcare systems.

WHO’s Technical Lead for Arboviruses, Dr Diana Rojas-Alvarez said the warning was being sounded early to give countries a fighting chance.

“We are raising the alarm early so countries can prepare early through surveillance, mosquito control, and public awareness-to avoid overwhelming health services,” she explained

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Kogi Leads in Health Insurance Coverage, Expands Affordable Care for Workers and Retirees

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Kogi State has emerged as Nigeria’s top-performing state in insurance coverage for adults, with 11% of its population enrolled, according to new 2023 data from StatiSense and EFInA. This figure places Kogi ahead of Lagos (9%), Oyo (7%), and the Federal Capital Territory (6%), underscoring the state’s commitment to expanding quality, affordable healthcare.

At the center of this progress is the Kogi State Health Insurance Agency (KGSHIA), led by Dr. Kunle Aledare, whose people-centered approach has driven aggressive enrollment, rural outreach, and partnerships that deliver inclusive, sustainable health financing. Thousands of rural and underserved residents can now access essential health services without fear of financial ruin.

Government Spokesperson, Kingsley Femi Fanwo, noted:

“This data confirms that Governor Ahmed Usman Ododo’s administration is deeply committed to improving the health and wellbeing of Kogites. With Dr. Aledare’s leadership, we are not just building hospitals but a healthcare system that truly works for everyone.”

Fanwo added that other states are already studying the Kogi model as the administration moves closer to universal health coverage.

In a further push to extend affordable healthcare, the Kogi State Government recently signed a landmark pact with the Nigeria Union of Local Government Employees (NULGE), providing Local Government staff access to affordable insurance under the state scheme. The Secretary to the State Government, Mrs. Folashade Ayoade, signed the agreement on behalf of the state, describing it as a “game changer.”

Fanwo explained that the initiative also covers retirees, with thousands of Kogi pensioners already enrolled and registration ongoing for others.

“We are actively onboarding our retirees, aligning with President Bola Ahmed Tinubu’s commitment to ensure cheap, quality, and accessible healthcare for pensioners and low-income earners,” he stated.

To support the rollout, the government is upgrading over 200 Primary Healthcare Centres across the state to guarantee grassroots access to quality care.

Fanwo hailed the Federal Government for its support, assuring civil servants, Local Government workers, and retirees that the Ododo administration will continue to build a healthy, empowered, and productive population as the foundation for sustainable development.

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